Peptide Argireline: Your Botox Alternative With Zero Side Effects

peptide argireline 

Discover the Top 3 Ways the Peptide Argireline can Help Improve Your Skin

The peptide argireline is a staple in many of our skin care products.  It’s skin friendly to all types, there are no known side effects, and everyone can benefit from it regardless of your age, lifestyle or skin color.  The is no downtime if you use it, and you can use it daily.  What’s not to like?  It’s one of our favorite active ingredients. 

What is the Peptide Argireline?

Argireline is a big deal on social media and in skin care conversations with experts.  It’s even endorsed by celebrity surgeon, Dr. Mehmet Oz. 

Although it is nicknamed “Botox in a jar,” Argireline (acetyl hexapeptide-3 or acetyl hexapeptide-8)is not a toxin, like botox. 

The plant-derived compound is, however, similar to Botox in its mechanism of action as it freezes nerve-to-muscle potential.  That the chain of peptides that make up the compound limits the ability of neurotransmitters to activate movement in your facial muscles (a process known as exocytosis).

By relaxing the nerves that send signals to facial muscles, subtle facial expressions are limited and reduced, and wrinkles are subsequently reduced.

History of Peptides in Skin Care

Anyone that's read a blog post of mine knows my passion for history.  My favorite topic in high school was world history, and it would be amiss if I stopped delving into the history of things that I find some much interest in.

The use of peptides is a fairly new process.  Peptides therapies started taking a notable role in the 1920's.  There are currently over 60 peptides approved for therapy and use, and more enter the study phase at a considerable rate.  As of right now, there are over 150 peptides in the study phase. 

How Can the Peptide Argireline Help My Skin?

There are three key benefits to regularly using the peptide Argireline:

Prevents the muscle movement that leads to wrinkle formation. Everyone is trying to mimic Botox's contenders, and so far, argireline is one of the best contenders. Argireline is a peptide that affects the nerve-to-muscle communication so that the muscles can’t adequately contract.

Promotes collagen production and optimizes the function of collagen, which both fight fine lines.  By increasing the production of collagen, the protein responsible for firm, healthy skin, it also helps to keep fine lines and wrinkles from forming.  As we age, the body produces less and less collagen. In fact, after the age of 20, a person produces about 1 percent less collagen in the skin each year. Moreover, environmental free radicals (from things like excessive sunlight exposure, smoking, pollution, etc.) can degrade collagen proteins. The result is skin that becomes thinner and more fragile with age. By promoting collagen production, Argireline may be able to increase skin firmness.

Improves moisture levels in the skin.  Argireline is known to improve moisture levels in the skin. And hydrated skin is always going to look more youthful than dry skin.

Supportive Medical Studies

According to a study published in the International Journal of Cosmetic Science, when Argireline is used at a 5% concentration it has the ability to decrease wrinkles up to 30% when applied once daily for 28 days. Thus, anyone looking to smooth out wrinkles caused by repeated muscle movement in areas such as the forehead and around the eyes may benefit from topical application of Argireline.

According to Medical National Institutes of Health, Argireline, developed as a topical mimetic of Botox, is a acetyl hexapeptide, patterned after the N-terminal end of the protein Synaptosomal-associated protein 25 (SNAP-25).  Argireline competes with SNAP-25 for the binding with vesicle-associated membrane protein (VAMP). This formation of a ternary Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor (SNARE) complex resulting in the inhibition of neuronal exocytosis. As a result, Argireline inhibits the release of acetylcholine6 and reduces repetitive contraction of the intrinsic muscles of facial expression, thereby decreases hyperkinetic facial lines or expression wrinkles7. However, unlike Botox, the acute toxicity is insignificant.  In addition, Argireline has been found to be effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice daily treatment.

We have two best selling products that include the peptide Argireline:

Anti Aging Eye Serum | Plant Derived Firming & Brightening

Naturally brighten eyes, reduce dark circles, and firm skin with plant derived ingredients like alpha lipoic acid, GABA, vitamin c, vitamin k, and peptides.

Our natural anti aging eye serum is formulated to help reduce dark circles, puffy skin, and increase hydration to repair crepey skin.   

This super hydrating gel serum will put the spring back in your delicate eye skin.  Have brighter eyes and less puffiness with important ingredients like alpha lipoic acid, argireline, DMAE, GABA, peptides, and vitamin c.

The rollerball applicator is like a mini massage all around your eyes, which feels fantastic, and the scent reminds us of a lemon dessert.   


  • Naturally tone eye area.
  • Soothing and hydrating relief anytime.
  • Lighten dark circles with arnica, vitamin c, vitamin k, and peptides.


Give anti aging eye serum a good shake and gently roll serum around eyes anytime, day and/or night.   

Each product is made fresh the day you order it. 

Enjoy free shipping in the US. 

Chemical free, synthetic free, paraben free, sulfate free, cruelty free.  Organic and earth derived ingredients. Made with love, one order at a time.

Try Me Size:


Aloe barbadensis (Organic Aloe) Leaf Juice, Alpha Lipoic Acid, Ananas Comosus (Pineapple) Extract, Argireline (Acetyl Hexapeptide-8 EcoCert / Naturally Derived), Arnica Essential Oil, Avocado Oil, Vaccinium Myrtillus (Organic Bilberry) Extract, Broccoli Oil, Carica Papaya (Papaya) Extract, Carica Papaya (Green Papaya) Extract, Carnosine, Centella Asiatica, Chamomile Essential Oil, Vaccinium macrocarpon (Organic Cranberry) Extract,  Cucumber Extract (contains Vitamin K), Dimethylaminoethanol (DMAE), Elderberry Extract, Eyeseryl (Acetyl Tetrapeptide-5 EcoCert / Naturally Derived), GABA, Glycerin, Green Tea Extract, Saccharum officinarum (Organic Sugar Cane) Extract, Hyaluronic Acid, Hydrolyzed Rice Protein, Acer Saccharinum (Organic Sugar Maple) Extract, Lecithin, Magnesium Ascorbyl Phosphate (Vitamin C), Matrixyl 3000 (Palmitoyl Oligopeptide (and) Palmitoyl Tetrapeptide-7 EcoCert / Naturally Derived), Niacinamide, Citrus auranium dulcis (Organic Orange) Fruit Extract, Citrus medica limonum (Organic Lemon) Extract, Regu-Age (EcoCert / Naturally Derived), Rose Damascena (Rose) Distillate, Salix alba (White Willow bark) xtract, Sea Kelp Bioferment, Melaleuca alternifolia (Tea Tree) Essential Oil, Vitamin E (Tocopherol), Tomato Seed Oil


This is the perfect all around eye product that is 100% natural and plant derived.  No chemicals here, just clean wholesome goodness for your healthiest eyes.

Argireline:  Argireline is a non irritating amino acid derived from natural protein that can relax facial muscles, which can lessen the depth of wrinkles and the signs of aging. 

Arnica Essential Oil:  Proven to help reduce dark circles under eyes, and is an anti-inflammatory, an added benefit as we combat the environmental and biological effects of aging.

DMAE:   Is naturally derived and will firm sagging skin. Not only are it’s effects immediate – but also cumulative, and it’s benefits accrue over time.

GABA:  A naturally derived amino acid that is well known for relaxing the skin, as a topical tranquilizer.

Magnesium Ascorbyl Phosphate:  One of the most important skin ingredients available, it is an antioxidant and transforms into vitamin c when applied topically. It is known for wound healing, collagen production, corrects pigmentation issues, and improves elasticity.

Restorative Cream with Peptides and Botanicals

peptide argireline

Naturally hydrate, repair, reverse damage and quench skin with this light serum. Features anti aging ingredients Argireline, Niacinamide, Tripeptides, Vegan Collagen and Vitamin C.


Our restorative cream with peptides and botanicals has a star studded list of plant based ingredients that are all proven to help your skin look restored, supple, soft and younger looking.

Enjoy the significant benefits of peptides and other active ingredients that will put the spring back into your skin.   

You will immediately feel that your skin is quenched and hydrated.


  • Repair damaged, aging skin.
  • Reverse damage with peptides and active ingredients.
  • Protect and fight further damage. 
  • Significant hydration.


Apply restoration cream to clean dry skin day and / or night. You can include eye and neck areas if you wish.

Made fresh the day you place your order.

All orders ship free in the US.

Chemical free, synthetic free, paraben free, sulfate free, cruelty free. Organic and earth derived ingredients. Made with love, one order at a time.

Try Me Size:


Achillea Millefolium Extract , Actigym (Bacillus/Soybean Ferment Extract Ecocert / Naturally Derived), Alchemilla Vulgaris Extract, Algae Extract, Aloe barbadensis (Organic Aloe) Juice, Alpha Lipoic Acid, Althea officinalis (Organic Marshmallow Root) Extract, Anthemis nobilis (Roman Chamomile) Distillate, Aphanizomenon flos-aqua (Blue Green Algae) Tincture, Argireline (Acetyl Hexapeptide-8 EcoCert / Naturally Derived), Avena sativa (Oat) Extract, Azadirachta indica (Neem) Oil, Camellia sinensis (Organic Green Tea) Extract, Bacillus Ferment (Vegan), Cannabis sativa (Hemp) Oil, Carnosine, Centella Asiatica, Citric Acid, Cocos nucifera (Organic Coconut) Oil, Ginseng Extract, Green Tea Extract, Elderberry Extract, Hibiscus Extract, Jasmine Essential Oil, Lavendula angustifolia (Organic Lavender) Distillate, Malva Sylvestris (Mallow) Extract, Persea americana (Avocado) Oil, Melissa Officinalis Leaf Extract, Mentha Piperita (Peppermint) Leaf Extract, Magnesium Ascorbyl Phospate (Vitamin C), Mushroom Extract, Primula Veris Extract, Niacinamide, Prunus dulcis (Sweet Almond) Oil, Pseudoalteromonas Ferment Extract, Rosmarinus Officinalis (Rosemary) Oleoresin, Salix nigra (Black Willow Bark) Extract, Silybum marianum (Organic Milk Thistle) Extract, Matrixyl 3000 (Palmitoyl Oligopeptide (and) Palmitoyl Tetrapeptide-7 EcoCert / Naturally Derived), Simmondsia Chinensis (Jojoba) Oil, Stellaria media (Organic Chickweed) Extract, Squalane (Vegan), Tocopherol (Vitamin E), Urtica Dioica (Organic Nettle Leaf) Extract, Tocopherol (Vitamin E), Tomato Seed Oil, Trylagen (Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide 10 Citrulline, Tripeptide 1 Ecocert / Naturally Derived), Ulmus fulva (Organic Slippery Elm) Extract, Vegan Collagen, Vegetable Glycerin, Veronica Officinalis Extract, Vitis vinifera (Grapeseed) Oil, Ylang Ylang Essential Oil, Hamamelis virginiana (Witch Hazel)


If you're looking for an organic, natural very good all around cream that is hydrating, this is the perfect choice for you.

Key Ingredient Highlights:

Argireline: Argireline is part of the peptide family, and has been proven to reduce the degree of existing facial wrinkles.  Key to any ante aging face product.

Hibiscus Extract: Hibiscus flowers have strong anti-oxidant properties, can prove skin elasticity and increase tone. 

Mushroom Extract: Can increase collagen production and increase firmness in skin.

Plant Derived Pseudoalteromonas Ferment Extract: Helps reduce the appearance of facial wrinkles associated with the aging process by increasing collagen, and increases firmness in the skin.  An important pick for our restoration cream.

Tripeptides: Proven to reduce the depth of wrinkles significantly, as well as increase collagen production, and increase suppleness.


We love the peptide Argireline, and love the results it can help give skin with consistent use.  It’s suitable for everyone and anyone can benefit from it with affordability and zero side effects.