Peptide Argireline: Healthier Botox Alternative

peptide argireline

Discover the Top 3 Ways the Peptide Argireline can Help Improve Your Skin

The peptide argireline is a staple in many of our skin care products. It’s skin friendly to all types, there are no known side effects, and everyone can benefit from it regardless of your age, lifestyle or skin color. The is no downtime if you use it, and you can use it daily. What’s not to like? It’s one of our favorite active ingredients.

What is the Peptide Argireline?

Argireline is a big deal on social media and in skin care conversations with experts. It’s even endorsed by celebrity surgeon, Dr. Mehmet Oz.

Although it is nicknamed “Botox in a jar,” Argireline (acetyl hexapeptide-3 or acetyl hexapeptide-8)is not a toxin, like botox.

The plant-derived compound is, however, similar to Botox in its mechanism of action as it freezes nerve-to-muscle potential. That the chain of peptides that make up the compound limits the ability of neurotransmitters to activate movement in your facial muscles (a process known as exocytosis).

By relaxing the nerves that send signals to facial muscles, subtle facial expressions are limited and reduced, and wrinkles are subsequently reduced.

Our Multi Corrective Eye Cream included the peptide argireline and a long list of anti aging ingredients to help you look your very best.

History of Peptides in Skin Care

Anyone that's read a blog post of mine knows my passion for history. My favorite topic in high school was world history, and it would be amiss if I stopped delving into the history of things that I find some much interest in.

The use of peptides is a fairly new process. Peptides therapies started taking a notable role in the 1920's. There are currently over 60 peptides approved for therapy and use, and more enter the study phase at a considerable rate. As of right now, there are over 150 peptides in the study phase.

How Can the Peptide Argireline Help My Skin?

There are three key benefits to regularly using the peptide Argireline:

Prevents the muscle movement that leads to wrinkle formation. Everyone is trying to mimic Botox's contenders, and so far, argireline is one of the best contenders. Argireline is a peptide that affects the nerve-to-muscle communication so that the muscles can’t adequately contract.

Promotes collagen production and optimizes the function of collagen, which both fight fine lines. By increasing the production of collagen, the protein responsible for firm, healthy skin, it also helps to keep fine lines and wrinkles from forming. As we age, the body produces less and less collagen. In fact, after the age of 20, a person produces about 1 percent less collagen in the skin each year. Moreover, environmental free radicals (from things like excessive sunlight exposure, smoking, pollution, etc.) can degrade collagen proteins. The result is skin that becomes thinner and more fragile with age. By promoting collagen production, Argireline may be able to increase skin firmness.

Improves moisture levels in the skin. Argireline is known to improve moisture levels in the skin. And hydrated skin is always going to look more youthful than dry skin.

Our Multi Corrective Eye Cream included the peptide argireline and a long list of anti aging ingredients to help you look your very best.

Supportive Medical Studies

According to a study published in the International Journal of Cosmetic Science, when Argireline is used at a 5% concentration it has the ability to decrease wrinkles up to 30% when applied once daily for 28 days.

Thus, anyone looking to smooth out wrinkles caused by repeated muscle movement in areas such as the forehead and around the eyes may benefit from topical application of Argireline.

According to Medical National Institutes of Health, Argireline, developed as a topical mimetic of Botox, is a acetyl hexapeptide, patterned after the N-terminal end of the protein Synaptosomal-associated protein 25 (SNAP-25). Argireline competes with SNAP-25 for the binding with vesicle-associated membrane protein (VAMP). This formation of a ternary Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor (SNARE) complex resulting in the inhibition of neuronal exocytosis.

As a result, Argireline inhibits the release of acetylcholine6 and reduces repetitive contraction of the intrinsic muscles of facial expression, thereby decreases hyperkinetic facial lines or expression wrinkles7. However, unlike Botox, the acute toxicity is insignificant. In addition, Argireline has been found to be effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice daily treatment.

Our Multi Corrective Eye Cream included the peptide argireline and a long list of anti aging ingredients to help you look your very best.


We love the peptide Argireline, and love the results it can help give skin with consistent use. It’s suitable for everyone and anyone can benefit from it with affordability and zero side effects.

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Jeanette @

I'm a formulator and skin care expert, wife, parent, and fur baby mom. I specialize in active ingredient research and studies, and share that information with you via our blog and products. Please reach out anytime you have questions!

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